Ferritin in the red cells of normal subjects and patients with iron deficiency and iron overload

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Abstract
Red cell ferritin was measured in normal subjects and patients with Fe deficiency and Fe overload by radioimmunoassays with antibodies to liver (basic) and heart (acidic) ferritins. In most of the subjects examined, red cells contained greater amounts of heart type than liver type ferritin. The basic ferritin content reflected the abnormal body Fe status both in Fe deficiency and Fe overload while the acidic ferritin content was less closely related to the Fe status. The 2 immunologically different red-cell ferritins probably represent distinct ferritin molecules and may have different metabolic functions within heme synthesizing erythroid cells.