THE EFFECT OF D-LYSERGIC ACID DIETHYLAMIDE ON THE MELANOPHORES OF THE TOAD BUFO ARENARUM UNDER DIFFERENT EXPERIMENTAL CONDITIONS

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Abstract
Parenteral administration of D-lysergic acid diethylamide in doses of 0.1 mg per animal, produced bleaching of the skin in dark adapted Bufo arenarum toads. No melanophore-concentrating activity of lysergic acid was found in vitro. The bleaching effect of the drug can also be demonstrated in toads with destruction of the hypothalamic-hypophysial pathway. It is therefore assumed that lysergic acid does not act on the pars intermedia via the hypothalamus.