The Saga of Thalidomide

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Abstract
PolyneuritisEarly in 1960 isolated reports were received by Burley,72 of Distillers Company (Biochemicals), Limited, from various parts of Great Britain describing symptoms and signs suggestive of peripheral neuritis occurring in patients receiving thalidomide regularly for periods of six months or more. Florence,73 however, recorded the first report in the literature in December, 1960. In 4 patients polyneuritis had developed while they were taking thalidomide, and he thought that the symptoms could possibly be a toxic effect of the drug. Kuenssberg et al.74 soon added 5 similar cases in January, 1961. It was not till the more detailed report of . . .