Transformation of Human Embryonic Fibroblasts by Photodynamically Inactivated Herpes Simplex Virus, Type 2 at Supra-optimal Temperature
- 1 February 1976
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 30 (2) , 257-261
- https://doi.org/10.1099/0022-1317-30-2-257
Abstract
Summary Infection of human embryonic fibroblast cell monolayers with neutral red and light-inactivated herpes simplex virus, type 2 (HSV-2) at supra-optimal temperature (42 °C) resulted in persistence of viable cells in suspension culture at 37 °C which have properties in common with virus transformed cells: formation of cell aggregates, HSV-2-specific antigens and colony formation in soft methyl cellulose medium. These data are consistent with the idea that photodynamic inactivated HSV-2 has potential oncogenic activity.Keywords
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