NMR Of Nucleic Acids; From Spectrum To Structure

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Abstract
Nucleic acids are perhaps the most intensively studied molecules found in nature, which is not too surprising in view of their role as carriers of genetic information. It has been a deep-rooted belief among molecular biologists that structure dictates function and, therefore, these studies have often involved the elucidation of structural aspects of these molecules, be it the linear base sequence or the three-dimensional arrangement of their nucleotide units. In a similar spirit it has been a deep-rooted belief among NMR spectroscopists that ‘ their ’ field of spectroscopy should be able to contribute to the elucidation of the structure and dynamics of molecules, in particular, biomolecules, in a way unparalleled by other forms of spectroscopy. Over the last few years this goal has come within reach thanks to the development of multidimensional NMR techniques which provide the necessary spectral resolution for the successful interpretation of the complicated spectra of biomolecules. Triggered off by the development of two-dimensional NMR, an avalanche of NMR studies on nucleic acids has appeared (1).

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