Pupillary changes induced by circulatory arrest

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Abstract
Pupillary changes induced by circulatory arrest were studied in cats following intradural section of the oculomoter nerve, preganglionic cervical sympathectomy, or interruption of both pathways to the same pupil. Both the sympath-ectomized and parasympathectomized pupils dilate synchronously with the normal pupil after 2 to 4 min. of circulatory arrest. When both innervations to the same pupil are interrupted, however, dilatation does not occur until the circulation is restored. Post-ischemic constriction to less then preischemic size of the parasympathetically denervated pupil was seen in 50% of animals with chronic oculomotor nerve section. This response was not abolished by cervical sympath-ectomy but did not occur when circulatory arrest was induced in animals with acute oculomotor nerve section. It is suggested that both dilatation of the totally denervated pupil and constriction of the parasympathetically denervated pupil are mediated by circulating neurohumors rather than by direct neural connections with the central nervous system.

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