A SIMPLE BLOOD TRANSFUSION TECHNIQUE IN THE UNANAESTHETIZED MOUSE.

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Abstract
A blood transfusion technique in mice is described, in which no anesthesia is necessary and in which both donor and recipient mice can be used repeatedly. Transfusion time averages 40 sec., surgical trauma and use of anticoagulant being kept at a minimum. Corticotropin levels were not measurable in normal non-stressed mice, but readily detectable in adrenalectomized mice: Four days after adrenalectomy the blood corticotropin increased significantly, the concentration being about 0. 25 milli-units/ml. Normal TSH (thyroid stimulating hormone) levels in mouse blood were not detectable and were thus lower than normal TSH levels in the rat. A significant rise in blood TSH was observed after administration of propylthiouracil (PTU) for 3 weeks.

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