Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA
- 10 April 2001
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 11 (8) , 1053-1056
- https://doi.org/10.1016/s0960-894x(01)00128-7
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) ProdrugsAntiviral Chemistry and Chemotherapy, 1997
- HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral InfectionsAntiviral Chemistry and Chemotherapy, 1997
- Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivityBioorganic & Medicinal Chemistry Letters, 1996
- Cidofovir, a New Agent with Potent Anti-Herpesvirus ActivityAntiviral Chemistry and Chemotherapy, 1996
- Activity of the (R)-Enantiomers of 9-(2-Phosphonylmethoxypropyl)-Adenine and 9-(2-Phosphonylmethoxypropyl)-2,6-diaminopurine against Human Immunodeficiency Virus in Different Human Cell SystemsBiochemical and Biophysical Research Communications, 1996
- Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular MetaboliteJournal of Medicinal Chemistry, 1996
- Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonatesAntimicrobial Agents and Chemotherapy, 1993
- Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenineAntiviral Research, 1992
- Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesisAntimicrobial Agents and Chemotherapy, 1991
- Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidinesAntiviral Research, 1987