Inhibition of multiplication of parainfluenza 3 virus in prostaglandin-treated WISH cells
- 1 December 1975
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 49 (4) , 377-380
- https://doi.org/10.1007/bf01318248
Abstract
Summary Influence of prostaglandins E2 (PGE2) and F2α (PGF2α) on multiplication of myxovirus parainfluenza 3 was investigated. At concentrations of 0.01–1 µg/ml prostaglandins had no direct cytotoxic effects. PGE2 and PGF2α inhibited multiplication of parainfluenza 3 virus at concentrations 0.1–10 µg/ml. The inhibitory effect was most pronounced when the prostaglandins were added to medium for the whole period of virus multiplication (48 hours) while little or no effect was found when prostaglandins were added before virus inoculation or for 2 hours after infection. It is suggested that prostaglandins exert an inhibitory effect on the replication phase of the virus by influencing the growth of the WISH cells.Keywords
This publication has 18 references indexed in Scilit:
- The role of adenosine 3′:5′-cyclic monophosphate in the division of WI 38 cells. The cellular response to prostaglandin E1 and the effects of an cyclic adenosine 3′:5′-cyclic monophosphate analogue and prostaglandin E1 on cell divisionBiochemical Journal, 1974
- Effects of dibutyryl-cAMP on adenovirus replication in different cell linesVirology, 1973
- Elevation of the intracellular levels of cyclic adenosine monophosphate during in vitro infection of transmissible gastroenteritis virusArchiv für die gesamte Virusforschung, 1973
- Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts.1972
- EFFECT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE ON CELL PROLIFERATIONThe Journal of cell biology, 1972
- Difference in the Cyclic Adenosine 3′,5′-Monophosphate Levels in Normal and Transformed CellsNature New Biology, 1972
- AnnouncementsNature, 1972
- Prostaglandin E 1 Effects on Adenosine 3′:5′-Cyclic Monophosphate Concentration and Phosphodiesterase Activity in FibroblastsProceedings of the National Academy of Sciences, 1972
- The effect of prostaglandins on cyclic AMP production and cell proliferation in thymic lymphocytesBiochemical and Biophysical Research Communications, 1971
- Conditions Leading to Enhanced Response to Glucagon, Epinephrine, or Prostaglandins by Adenylate Cyclase of Normal and Malignant Cultured CellsProceedings of the National Academy of Sciences, 1971