Studies of active and passive immunity in animals inoculated with Toxoplasma gondii

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Abstract
Cytoplasm-modifying antibodies as demonstrated by the Sabin-Feldman dye test were elicited in the guinea pig after inoculation of phenol-killed toxoplasma organisms and the addition of an adjuvant to the suspension induced immunity to reinfection in the animals. Protection from reinfection was also provided by recovery from laboratory-induced infection. Passive immunity studies were conducted using pooled antiserum from actively immunized guinea pigs. A slight increase in average survival time was shown in mice when the sera were used. The exception was in the case of serum from guinea pigs injected with an aqueous suspension of phenol-killed organisms. When "accessory factor" was incorporated with these antisera there was an additional increase in survival time in mice, but this increase was not statistically significant in every case. Neither vaccination nor recovery from experimental infection, even in the presence of very high titers of dye test antibodies, completely prevented the persistence of toxoplasma in various organs of the guinea pigs which had been challenged.

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