Chlorocardicin, a monocyclic .BETA.-lactam from a Streptomyces sp. I. Discovery, production and biological activities.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (2) , 133-138
- https://doi.org/10.7164/antibiotics.38.133
Abstract
Chlorocardicin is a new monocyclic β-lactam produced by a Streptomyces sp. It is structurally related to nocardicin A but differs in having a m-chloro substituent on the p-hydroxyphenylglycine unit. The biological activity of chlorocardicin was similar to nocardicin A but the former showed less antagonism in complex media. Moderate in vitro activity was Observed against Enterobacteriaceae and Pseudomonas aeruginosa. Chlorocardicin showed low activity against Staphylococcus aureus whereas nocardicin A was inactive. Both compounds Were shown to be strongly potentiated by antibiotics that inhibit peptidoglycan biosynthesis and Were antagonized by selected L-and D-amino acids.This publication has 0 references indexed in Scilit: