Evidence for the presence of α‐adrenoceptors in the central thermoregulatory mechanism of rabbits

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Abstract
1 The effects of intracerebroventricular administration of some α- and β-adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated. 2 Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active. 3 The noradrenaline response was blocked by α-adrenoceptor blocking agents while β-adrenoceptor antagonists had no effect. 4 α-Methyl-noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline. 5 The possible presence of α-adrenoceptors in the central thermoregulatory mechanisms is suggested.