Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

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Abstract
Serum 5.alpha.-dihydrotestosterone (DHT) and testosterone (T) were measured in 78 normal men aged between 12-89 yr, separating DHT and T by celite microcolumn and using radioimmunoassay. In 4 age groups of young (20-39 yr), middle aged (40-59 yr) and old (60-79 yr and 80-89 yr) men, the mean .+-. SEM [standard error of the mean] for serum DHT were 98 .+-. 12, 91 .+-. 9, 82 .+-. 7 and 54 .+-. 15 (ng/100 ml), respectively. Corresponding values for T were 696 .+-. 27, 698 .+-. 18, 624 .+-. 20 and 457 .+-. 21 (ng/100 ml). DHT and T showed significant correlation in each age group: r=0.625, P < 0.05 (young men), r=0.727, P < 0.02 (middle aged men), r=0.673, P < 0.05 and r=0.734, P < 0.02 (old men), respectively. There was a significant decline in DHT and T levels of 80-89 yr age group compared to those of 30-39 yr age group (P < 0.05 and P < 0.005, respectively). There was no significant changes in DHT and T levels between other age groups. After 3 daily i.m. injections of 4000 IU human chorionic gonadotropin (hCG) levels of serum DHT of the young group (20-32 yr) and old group (72-78 yr) increased 2.6 times and 1.9 times more, respectively. T increased 2.7 times and 1.4 times more, respectively.

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