Naltrexone Antagonism of Exploration in the Rat
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 9 (1) , 49-51
- https://doi.org/10.3109/00207457909169640
Abstract
Adult male Sprague Dawley rats were injected with low doses of the narcotic antagonist Naltrexone or vehicle and tested for motor activity upon an automated platform. A single exposure of four consecutive ten minute periods was employed. The drug caused dose-related declines in activity which could be dissociated from ataxia related nonspecific side effects. Endogenous opiates may be involved in exploration.Keywords
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