The effect of PMSG dose on the incidence of chromosomal anomalies in mouse embryos fertilized in vitro
- 1 July 1977
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 50 (2) , 275-280
- https://doi.org/10.1530/jrf.0.0500275
Abstract
Chromosomal analysis of 1st-cleavage mouse embryos obtained by fertilization of TO eggs with TO spermatozoa in vitro revealed that the incidence of polyploidy was proportional to the dose of PMSG [pregnant mare''s serum gonadotropin] given to the donor females. The dose-response was linear, with the level of polyploidy rising from 8.0% with a PMSG dose of 1.5 IU/female to 20.8% with 10.0 IU/female. A total of 64 polyploid embryos were found among the 452 examined and in all cases the polyploidy was the result of polyspermy or fertilization by diploid spermatozoa.This publication has 1 reference indexed in Scilit: