Stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblasts

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Abstract
Escherichia coli, Shigella, Salmonella and cholera endotoxins stimulated prostaglandin E (PGE) productiion by cultured human synovial and foreskin fibroblasts. The minimal effective dose of Shigella endotoxin was 2 .mu.g/ml and a maximal response was observed at 10 .mu.g/ml. PGE stimulation was first detected 7 h after addition of cholera endotoxin. Stimulation by Shigella endotoxin of both PGE and hyaluronic acid production was inhibited by indomethacin and aspirin. PGE may be a mediator of joint inflammation induced by endotoxins.