Ontogeny of synaptic phosphoproteins in brain.
- 1 August 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (8) , 4037-4041
- https://doi.org/10.1073/pnas.75.8.4037
Abstract
The ontogeny of 2 endogenous substrates for cyclic AMP-dependent protein kinase (ATP:protein phosphotransferase; EC 2.7.1.37) was studied in rat and guinea pig cerebrum. These endogenous substrates, referred to as proteins Ia and Ib, were shown in other studies to be specific to nervous tissue and to be enriched in the synaptic membrane and synaptic vesicle fractions of adult brain. In this present study, proteins Ia and Ib increased markedly during the time of major synaptogenesis in rat cerebrum and guinea pig cerebrum, in which the morphological development of synapses is predominantly postnatal and prenatal, respectively. Similar results were obtained by measuring endogenous phosphorylation of proteins Ia and Ib in the synaptic membrane fraction or by measuring phosphorylation of extracted proteins Ia and Ib with added protein kinase.This publication has 14 references indexed in Scilit:
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