INTERMEDIATES IN THE METABOLISM OF STEROIDS BY PENICILLIUM LILACINUM
- 1 June 1962
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 83 (6) , 1327-+
- https://doi.org/10.1128/jb.83.6.1327-1331.1962
Abstract
Nonproliferating cells of Penicillium lilacinum Thorn metabolized progesterone successively to 2O-[beta]-hydroxy-4-pregnen-3-one, testosterone, androstenedione, and testololactone. Testosterone and androstenedione were readily interconvertible. ll-[alpha]-Hydroxyprogesterone was transformed in an analogous way and its intermediate, 11-[alpha], 20-[beta]-dihydroxy-4-pregnen-3-one, was isolated and identified by a combination of microbiological and chemical methods.This publication has 5 references indexed in Scilit:
- Formation of testosterone acetate by Saccharomyces fragilisBiochimica et Biophysica Acta, 1960
- PATHWAY OF PROGESTERONE OXIDATION BY CLADOSPORIUM RESINAEJournal of the American Chemical Society, 1960
- [20beta-Hydroxysteroid dehydrogenase. 1. Culture of Streptomyces hydrogenans and induction of the enzyme].1960
- Paper Chromatography in Steroid DeterminationAnalytical Chemistry, 1956
- MICROBIOLOGICAL TRANSFORMATIONS OF STEROIDS. IX. DEGRADATION OF C21 STEROIDS TO C19 KETONES AND TO TESTOLOLACTONEJournal of the American Chemical Society, 1953