Allergic Eczematous Sensitivity to Aminophylline

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Abstract
Recently Tas and Weissberg1reported a case of allergic sensitivity to aminophylline in a 52-year-old pharmacist. For about one year he had prepared 600 aminophylline suppositories a week. Some weeks, after the start of this work, he had complained of an itching skin disorder on his hands, arms, and face. On examination there was redness and swelling, accompanied by papules, vesicles, and weeping on the hands and arms together with slight redness and papule formation on the face and scaling of the lips. Patch tests with many materials, but not including aminophylline, were negative. When the patient's work changed and he was no longer exposed to aminophylline his skin cleared. Several months later he again prepared aminophylline suppositories. After the first new contact he began to sneeze and wheeze, and his skin eruption reappeared. A patch test to 1% aminophylline was strongly positive. A patch test

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