Suppression of the Progress of Disseminated Pancreatic Cancer Cells by NK4 Plasmid DNA Released from Cationized Gelatin Microspheres
- 1 July 2004
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 21 (7) , 1109-1118
- https://doi.org/10.1023/b:pham.0000032996.95518.dc
Abstract
Purpose. NK4, composed of the NH2-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts as a potent angiogenesis inhibitor. This study is an investigation to...Keywords
This publication has 51 references indexed in Scilit:
- Nanoparticulate DNA Packaging Using Terpolymers of Poly(lysine-g-(lactide-b-ethylene glycol))Bioconjugate Chemistry, 2003
- Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude miceCancer Gene Therapy, 2002
- Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomasCancer Gene Therapy, 2002
- Targeting Angiogenesis and HGF Function Using an Adenoviral Vector Expressing the HGF Antagonist NK4 for Cancer TherapyMolecular Therapy, 2002
- Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survivalGene Therapy, 2001
- Kringle 1–4 of Hepatocyte Growth Factor Inhibits Proliferation and Migration of Human Microvascular Endothelial CellsBiochemical and Biophysical Research Communications, 2000
- Hepatocyte Growth Factor (HGF) as a Tissue Organizer for Organogenesis and RegenerationBiochemical and Biophysical Research Communications, 1997
- Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppressionNature Medicine, 1995
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.The Journal of cell biology, 1992
- In vitro iodination of low complexity nucleic acids without chain scissionBiochemistry, 1976