Staphylococcal Enterotoxin: Increased Vomiting Incidence in Monkeys Following Subemetic Doses of Dihydroergotamine

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Abstract
Summary Subcutaneous injection of subemetic dose of dihydroergotamine methane-sulfonate increases the number of Macaca mulatta which vomit following oral administration of staphylococcal enterotoxin. The possibility that increased incidence of vomiting might be due to summation effects of 2 similar pharmacological compounds has been considered, but no adrenolytic effect of enterotoxin corresponding to that of DHE-45 has been found. The other drugs tested have not significantly affected the incidence of emesis in monkeys following feeding of enterotoxin.