LIPOSOME-INCORPORATED CORTICOSTEROIDS .1. INTERACTION OF LIPOSOMAL CORTISOL PALMITATE WITH INFLAMMATORY SYNOVIAL-MEMBRANE
- 1 January 1979
- journal article
- research article
- Vol. 60 (2) , 142-150
Abstract
Cortisol palmitate-containing liposomes were stable in rheumatoid synovial fluid at 37.degree. C. At 2 h after the intra-articular injection of such liposomes into experimentally arthritic rabbits, relatively high proportions of the steroid and lecithin components were recovered from the synovialis. The level of cortisol in the tissue at this time was inversely related to the chronicity of the inflammation. The degree and duration of the anti-inflammatory activity of the liposomes was greatest in the initial acute phases of the inflammation.This publication has 22 references indexed in Scilit:
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