Evolutionary significance of the renal excretion of transferrin half-molecule fragments
- 1 February 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 201 (2) , 417-419
- https://doi.org/10.1042/bj2010417
Abstract
It is generally thought that the duplicated structure of serum transferrin in vertebrates arose by gene duplication and fusion from a small ancestral protein. We have found that the isolated domains of transferrin are rapidly lost from the bloodstream via the kidneys. Therefore we suggest that the ancestral transferrin was not a serum protein or, alternatively, that it was not as small as the half-molecule.This publication has 11 references indexed in Scilit:
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