Coeliac Disease: The Abolition of Gliadin Toxicity by Enzymes from Aspergillus Niger

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Abstract
Gliadin [the alcohol soluble fraction of wheat or rye gluten] from which carbohydrate was removed by treatment with carbohydrase from A. niger, was fed to coeliac patients in remission. Xylose absorption, mucosal morphology and brush-border enzymes were used to assess the toxicity of the carbohydrase-treated gliadin. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. The primary structure of the gliadin proteins was not altered by the enzyme treatment.

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