Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus
Open Access
- 1 March 1990
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 34 (3) , 484-486
- https://doi.org/10.1128/aac.34.3.484
Abstract
SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.This publication has 17 references indexed in Scilit:
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