Effect of Filtration Procedures on Immunogenic Activity and Safety of Formalinized Poliomyelitis Vaccine (Salk Type)

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Abstract
Seitz filtration of poliomyelitis vaccine pools during formaldehyde-inactivation process was found to lower their immunogenic activity. Monovalent vaccine pools in which filtration through Seitz filter pads during the inactivation process was either omitted or replaced by filtration through fritted glass filters, proved to be of higher antigenicity both in guinea pigs and in triply negative children. Routine safety tests in tissue culture carried out on such pools were consistently negative. Additional proof of the safety of such pools was provided by the absence of live poliovirus from large samples withdrawn as much as 5 days prior to the end of the inactivation period, and also by the use of these vaccines in the field.

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