CELLS INVOLVED IN CELL-MEDIATED AND TRANSPLANTATION IMMUNITY IN NORMAL OUTBRED RABBIT .11. ACCELERATED RESPONSE IN ONE-WAY MLR OF RABBIT WBC FROM SKIN ALLOGRAFT RECIPIENTS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 36  (1) , 25-31
Abstract
The relationship between allograft rejection and the response in the 1-way mixed leukocyte reaction (MLR) of the WBC [white blood cells] of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the allografted rabbit stimulated with cells from the allograft donor occurred on days 3-4 of culture and by day 6 the MLR response was down to control levels. This accelerated response by the allograft-sensitized cells was specific to stimulator cells from the allograft donor as stimulator cells from a 3rd party rabbit induced a normal MLR response by these cells, i.e., an optimal response on days 5-7 of culture. No evidence of cytotoxic cells was obtained in cultures of cells from allograft-sensitized rabbits.