Crystal and molecular structure of 4′-(acridin-9-ylamino)methanesulphonanilide hydrochloride, a compound showing antileukemic activity
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 11,p. 1334-1337
- https://doi.org/10.1039/p29740001334
Abstract
The title compound (VI) has antileukemic properties. An X-ray analysis shows it to be triclinic, a= 14·074(1), b= 6·864(1), c= 10·166(1)Å, α= 105·40(3), β= 101·60(2), γ= 86·07(3)°, Z= 2, space group P. The structure was solved by Patterson and Fourier methods. Refinement of 2070 diffractometer data reduced the R factor to 0·046. The acridine ring is slightly non-planar and the phenyl ring makes an angle of 77° with it. This latter appears to be a feature of the molecule rather than a crystal-packing requirement.Keywords
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