SUPPRESSION OF HUMAN MONOCYTE INTERLEUKIN-1 PRODUCTION BY THE PLANT ALKALOID TETRANDRINE
- 1 January 1989
- journal article
- research article
- Vol. 75 (1) , 47-51
Abstract
The bisbenzylisoquinoline alkaloid, tetrandine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be a value in the treatment of chronic inflammatory disease where IL-1 has a major role as an inflammatory mediator.This publication has 31 references indexed in Scilit:
- Increased release of interleukin-1 from mouse peritoneal macrophages in vitro after cisplatin treatmentInternational Journal of Immunopharmacology, 1987
- Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitroInternational Journal of Immunopharmacology, 1987
- InterleukinsAnnual Review of Medicine, 1986
- Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis.Journal of Clinical Investigation, 1984
- Fibroblast RNA and macrophage proteins (including the fibrogenic factor) in experimental silicosis.Environmental Health Perspectives, 1983
- Biological Properties of InterleukinsAllergy, 1983
- Human Alveolar Macrophage Growth Factor for FibroblastsJournal of Clinical Investigation, 1982
- Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENTJournal of Clinical Investigation, 1973
- Activity of a Macrophage Factor in Collagen Formation by SilicaNature, 1967
- AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGESThe Journal of Experimental Medicine, 1966