EXPERIMENTAL-THERAPY OF DISSEMINATED INTRA-VASCULAR COAGULATION BY STREPTOKINASE ADMINISTRATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (1) , 97-106
Abstract
Disseminated intravascular coagulation was induced in dogs by infusion of tissue thrombokinase. Its course was followed by coagulation tests, determination of the rate of microthrombosis and measurement of organ functions and O2 consumption. The therapeutic result of streptokinase administration at an early stage of pathological changes is seen by improvement of the disturbed organ functions and O2 supply and by the decrease in plasma Hb level. When streptokinase was administered at an advanced stage of orang damages, they remained irreversible, although the microvasculature was patent.