Regiospecific Oxidation of Methyl Groups in Dimethylanisoles
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (08) , 723-724
- https://doi.org/10.1055/s-1987-28061
Abstract
Dimethylanisoles in which one of the methyl groups is meta and the other is ortho or para are regiospecifically oxidized in high yield to the corresponding ortho- and para-substituted aldehydes by copper (II) and peroxydisulfate. Subsequent oxidation of the aldehydes with sodium chlorite furnishes the corresponding acids in excellent yield.Keywords
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