The Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS
- 1 April 2007
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (4) , 2063-2066
- https://doi.org/10.1128/iai.01565-06
Abstract
Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using the Himar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interrupted cylJ gene was characterized. cylJ , encoding a putative glycosyltransferase, and cylK , whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.Keywords
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