Gilles de la Tourette-Syndrom im Erwachsenenalter - Eine vernachlässigte Differentialdiagnose

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Abstract
Five adult patients with Gilles de la Tourett''s syndrome (GTS) are presented. Signs and symptoms began in childhood and/or adolescence in each patient, but were only once relevant enough to cause immediate medical attention. Due to the favourable long-term course, drug treatment is needed only in the most severe adult cases. According to the study of our patients and the pertinent literature there are no regularly associated neurological signs and symptoms in adulthood beyond the known GTS phenomena. Tardive dyskinesia and a variety of other aetiologically different brain disorders may carry GTS signs. To date, there are no biochemical and/or neurophysiological measures to differentiate GTS from other extrapyramidal diseases. GTS remains a phenomenological diagnosis that relies on clinical course and history.

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