Immune suppression and skin cancer development: regulation by NKT cells
Top Cited Papers
- 1 December 2000
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 1 (6) , 521-525
- https://doi.org/10.1038/82782
Abstract
Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.Keywords
This publication has 27 references indexed in Scilit:
- Bone Marrow NK1.1− and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host DiseaseThe Journal of Experimental Medicine, 1999
- MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and FunctionAnnual Review of Immunology, 1997
- Mouse NK1.1+ T cells: a new family of T cellsImmunology Today, 1996
- Peptide Binding and Presentation by Mouse CD1Science, 1995
- CD1 Recognition by Mouse NK1 + T LymphocytesScience, 1995
- CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.The Journal of Experimental Medicine, 1994
- SPECIFIC SUPPRESSION OF ALLOGRAFT REJECTION AFTER TREATMENT OF RECIPIENT MICE WITH ULTRAVIOLET RADIATION AND ALLOGENEIC SPLEEN CELLSTransplantation, 1988
- Depressed immunity and skin cancerImmunology Today, 1984
- Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated MiceScience, 1982
- Evidence for the generation of suppressor cells by ultraviolet radiationCellular Immunology, 1977