Cardiac hypertrophy and antihypertensive therapy
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 11 (5) , 427-433
- https://doi.org/10.1093/cvr/11.5.427
Abstract
Biochemical (myocardial DNA, RNA, and hydroxyproline) and humoral (plasma [PRA] and kidney [KRA] renin activity) factors were determined in spontaneously hypertensive rats (SHR) and normotensive Wistar controls (NR) before and following treatment with minoxidil or propranolol. Minoxidil (150 mg·litre−1 drinking water) effectively controlled blood pressure (17.3 kPa vs 24.9 kPa [130 mmHg vs 187 mmHg], P −1vs 3.4 ± 0.09 mg·g−1, P < 0.05); in both S HR and NR, KRA, and PRA were lowered by pranolol. Methyldopa which controlled blood pressure and lowered PRA led to a reversal of hypertrophy. Thus, although blood pressure control is obviously important for reversing cardiac hypertrophy, it may not be the sole factor for the development and reversal of cardiac hypertrophy.Keywords
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