Influence de la température sur le développement du virus Sindbis et la production d'interféron en cultures cellulaires

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Abstract
The development of Sindbis virus in mouse embryo fibroblasts was found to vary according to the temperature of incubation. An augmentation in these temperatures was followed by a prolongation of the lag period and a decrease in the final yield. At 38 °C, 39 °C, and 40 °C the virus titer was respectively 50%, 16%, and 1.3% of that observed at 36 °C.Interferon production at 38 °C was equal to, or greater than, at 36 °C but at 39 °C and 40 °C it was respectively 1.4 and 5 times lower than that found at 36 °C.These results permit us to presume that the inhibition of Sindbis virus development at supra-optimal temperatures cannot be attributed to an increase of interferon production.

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