Reticulum Cell Sarcomas Induced in Mice by Rauscher Virus2

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Abstract
Transplantable reticulum cell sarcomas were established from mice with advanced Rauscher disease by subcutaneous implantation of spleen fragments into syngeneic recipients. Six tumors developed among 96 (C57BL/6 × DBA/2)F1 (B6D2F1) and (C57BL/Ks × DBA/2)F1 (BkD2F1) recipients. Three transplantable lines were established morphologically and biologically resembling similarly produced tumors from spleens of B6D2FI mice with advanced Friend disease. Light and electron microscopy of the transplantable cell lines showed primitive hematopoietic or Iymphoreticular cells, and all 3 lines contained Rauscher virus. These tumors were different from the transplantable myeloid and lymphatic leukemias reported previously in mice inoculated with Rauscher virus. Attempts to establish reticulum cell sarcomas by the same technique in 119 BALB/c mice were uniformly unsuccessful.