Cytogenetic Findings in Pediatric T-Lymphoblastic Lymphomas: One Institution's Experience and a Review of the Literature
- 1 September 2005
- journal article
- review article
- Published by SAGE Publications in Pediatric and Developmental Pathology
- Vol. 8 (5) , 550-556
- https://doi.org/10.1007/s10024-005-0050-7
Abstract
Cytogenetic analyses of lymphomas commonly reveal nonrandom chromosomal abnormalities, but there are relatively few reports in childhood lymphoblastic lymphoma (LL). We retrospectively reviewed G-banded karyotypic analyses performed at Arkansas Children’s Hospital between 1990 and 2004. Six children (2 to 20 years old) had LL that presented as mediastinal or cervical masses and had a T-cell immunophenotype and clonal abnormalities. The cytogenetic findings in these 6 patients were as follows: 46,XX,−7,inv(9)(p11q12),der (12)t(7;12)(q11.2;p13),t(16;18)(p13.1;q21),+22 in patient 1; 47,XX,+9,del(9)(q11q22)x2 in patient 2; 72−119, XY,+X,+1,+1, inv(2) (p11q13),−3,+5,+6,+7,+10,−12,−16, −21,−21,−22,+mar in patient 3; 48,XY,+5,+20,t(7;9) (q32;q34) in patient 4; 47∼48,XX,der(10)t(10;14)(q23; q11.2),+12, del(12)(p12)x2, −14,del(16)(q22q22),+?add (19)(p13.3) in patient 5; and 48∼49,XY,+7,+8,t(11;19) (q23;p?13.3),+der(19)t(11;19)[cp20] in patient 6. Eleven chromosome breakpoints in 6 of our patients (7q11, 12p13, 16p13, 18q21, 9q11, 2p11, 2q13, 7q32, and 7q23) have been reported in other patients with acute lymphoblastic leukemia or LL and involved regions containing TEL, ABL, E2A, MLL, and T-cell receptor-α genes. A review of the cytogenetic findings of these and other cases of LL reveals that clonal aberrations are common and most frequently involve T-cell receptor gene regions. The aberrations show some features similar to those of acute lymphoblastic leukemia and are not unique to LL, thus furnishing additional evidence of the equivalence of these two diseases. The cytogenetic features of LL may be helpful in the diagnosis of pediatric lymphomas and undifferentiated neoplasms.Keywords
This publication has 38 references indexed in Scilit:
- Utility of WT1 as a Reliable Tool for the Detection of Minimal Residual Disease in Children with LeukemiaPediatric and Developmental Pathology, 2002
- MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemiaNature Genetics, 2001
- Precursor B-Cell Lymphoblastic LymphomaAmerican Journal of Clinical Pathology, 2001
- Variant (8;22) Translocation in Lymphoblastic LymphomaLeukemia & Lymphoma, 1996
- Paired box gene expression in Wilms' tumorJournal of Pediatric Surgery, 1994
- Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma with Mediastinal Mass—A Studv of 23 Children; Different Disorders or Different Stages?Leukemia & Lymphoma, 1994
- Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridizationGenes, Chromosomes and Cancer, 1993
- Distinct patterns of chromosome abnormalities characterize childhood non-Hodgkin's lymphomaBritish Journal of Haematology, 1992
- Cytogenetic Abnormalities in Childhood Acute Lymphoblastic LeukemiaJournal of Pediatric Hematology/Oncology, 1991
- Lymphoblastic lymphoma: Cytogenetic, pathologic, and immunologic studiesInternational Journal of Cancer, 1982