Altered Enzymes in Ageing Human Fibroblasts
- 1 July 1972
- journal article
- Published by Springer Nature in Nature
- Vol. 238 (5358) , 26-30
- https://doi.org/10.1038/238026a0
Abstract
Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.Keywords
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