Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride–dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds 1
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 495-500
- https://doi.org/10.1039/a706545k
Abstract
A one-pot synthesis of cystine-containing peptides is achieved by treatment of protected peptidyl resins with trimethylsilyl chloride–dimethyl sulfoxide/trifluoroacetic acid in the presence of anisole. This methodology has been successfully applied to the synthesis of highly active anti-HIV peptides conjugated with 3′-azido-3′-deoxythymidine.Keywords
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