Receptor Imaging by Pet and Spect: Focus on the Opiate Receptor
- 1 January 1993
- journal article
- review article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 13 (1-4) , 39-53
- https://doi.org/10.3109/10799899309073644
Abstract
Receptor imaging by PET and SPECT offers distinctive advantages over the more established flow/metabolism imaging methods, including improved chemical specificity and improved sensitivity in detecting changes in disease. Radioligands are available for PET and SPECT imaging of many neuroreceptors including the opiate receptor, the dopamine receptor and the muscarinic cholinergic receptor. A new focus of interest is the imaging and quantification of presynaptic neurotransmitter reuptake sites. Clinical applications of μ opiate receptor imaging are discussed for epilepsy, Alzheimer's disease and dementia.Keywords
This publication has 29 references indexed in Scilit:
- Parametric in vivo imaging of benzodiazepine receptor distribution in human brainAnnals of Neurology, 1991
- Quantification of mu and non–mu opiate receptors in temporal lobe epilepsy using positron emission tomographyAnnals of Neurology, 1991
- Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [11C]Diprenorphine and Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1991
- Multicompartmental Analysis of [11C]-Carfentanil Binding to Opiate Receptors in Humans Measured by Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1989
- Multicenter trial of naloxone in alzheimer's diseaseAnnals of Neurology, 1989
- Evidence for an enhanced role of GABA inhibition in visual cortical ocular dominance of cats reared with abnormal monocular experienceDevelopmental Brain Research, 1989
- Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET ImagesJournal of Cerebral Blood Flow & Metabolism, 1988
- Mu‐opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsyAnnals of Neurology, 1988
- Selective changes in μ, δ and ϰ opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patientsBrain Research, 1987
- Analgesic (sub anesthetic) nitrous oxide interacts with the endogenous opiod system: A review of the evidenceLife Sciences, 1986