Fowl Cholera: Induction of Cross-Protection in Turkeys with Bacterins Prepared from Host-Passaged Pasteurella multocida

Publisher Website
Google Scholar
Abstract
Modified fowl cholera bacterins prepared by inoculating agar medium with infected liver tissue from birds which died of acute fowl cholera induced 70% cross-protection [by immunoglobulin G induction] in turkeys, i.e., protection against a different immunologic type of P. multocida. Standard bacterins prepared from lyophilized and stored cultures showed variable cross-protection (0-40%). Repeated subculturing of the standard inoculum on agar reduced cross-protection. The protection with the modified or standard bacterins was comparable (80-100%) when immunity was challenged with the homologous strain. With lyophilization of P. multocida and subculturing on agar, antigens capable of inducing cross-immunity may be lost more readily than antigens capable of inducing homologous immunity.

This publication has 0 references indexed in Scilit: