Lymphocyte In Vitro Cytotoxicity: Mechanism of Lymphotoxin-Induced Tarcet Cell Destruction

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Abstract
Summary: Lymphotoxin-induced cell destruction in vitro is a progressive cytolysis occurring over 36 to 48 hr. This process was shown to be temperature and concentration dependent. Cell destruction was characterized by the following observations: a) LT does not bind to the target cell, b) it acts non-specifically, causing destruction of cells from many mammalian species, c) it causes lysis of red blood cells, and d) polyanions of similar charge compete and block the cytolytic action of LT. The mechanism of action of LT appears to be the result of LT interaction on membrane site(s) which are common to many different types of cells. The concept of LT as an important mediator of cell destruction in systems in which ymphocytes participate is discussed.

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