METABOLIC PATHWAYS OF CAROTENE TO VITAMIN A IN ANIMALS

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Abstract
Using pure standard preparations vitamin A acid could be produced from natural vitamin A aldehyde by treating with a dilute alkaline solution according to Cannizzaro''s reaction, judging from the findings of spectrophotometry and paper chromatography. Metabolic pathways of [beta]-carotene, vitamin A aldehyde and vitamin A alcohol under anerobic condition were studied using the intestine of rats, and it was demonstrated that the terminal fission of [beta]-carotene might take place, yielding protein-bound vitamin A aldehyde and [beta]-ionone. Further, the same experiments were performed under aerobic condition, and the fates of [beta]-carotene and vitamin A were studied. The results suggest that at the final step of vitamin A metabolism in the intestine, protein-bound vitamin A aldehyde might be converted to vitamin A alcohol and vitamin A acid.

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