IMMUNOPEROXIDASE LOCALIZATION OF LYMPHOCYTE SUBSETS IN THE HOST RESPONSE TO MELANOMA AND NEVI

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (6) , 2749-2753
Abstract
Using an avidin:biotin immunoperoxidase system with monoclonal antibodies to lymphocyte subsets the host response to human malignant melanoma and melanocytic nevi was investigated in frozen sections. Eight primary melanomas, 8 metastases, 3 dysplastic nevi and 2 dermal nevi were studied with antibodies T11, T4, T8 and B1. Sections were read in a semiquantitative manner by 2 observers. Virtually all lymphocytes in these lesions were T-cells (T11 positive). In all primary melanomas, in the majority of metastases, and in all dysplastic nevi, both T4- and T8-positive cells were present. In 2 of 8 metastases, tumor cells stained with T4, and in 1 case, melanoma cells stained with B1 antibody. The host response to melanoma involves primarily T-cells and includes both the helper:inducer (T4) and suppressor:cytotoxic (T8) subsets.

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