Effects of Colchicine and Vinblastine on Axonal Transport of Choline Acetyltransferase in Rat Sciatic Nerve1
- 1 April 1976
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 96 (4) , 486-494
- https://doi.org/10.1111/j.1748-1716.1976.tb10218.x
Abstract
The effects of colchicine (0.5-10-2 M) and vinblastine (10-2-10-5 M) upon axonal transport of choline acetyltransferase (CAT) and on nerve impulse conduction were investigated in the rat sciatic nerve. High concentrations of colchicine (0.5 M) and vinblastine (10-2 M) blocked completely both axonal transport of CAT and impulse conduction. Vinblastine (10-3 M) did not affect impulse conduction until 20-22 h after injection, but this concentration of vinblastine did block CAT transport; 5 .times. 10-5 and 10-4 M vinblastine blocked CAT transport but not impulse conduction. Colchicine (10-2 M and 10-1 M) were without effect on impulse conduction, but did produce substantial, although incomplete, block of CAT transport. Involvement of microtubules in transport of CAT was discussed.This publication has 23 references indexed in Scilit:
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