DNA alkylation and neuro-oncogenesis by 3,3-dimethyl-1-phenyltriazene
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 43 (1-2) , 105-109
- https://doi.org/10.1007/bf00685004
Abstract
The role of DNA alkylation by the neurooncogenic agent 3,3-dimethyl-1-phenyltriazene (DMPT) was investigated perinatally and in adult rats. Following a single subcutaneous injection of14C-DMPT (100 mg/kg) on the 21st day of gestation, the concentration of methylated purines was similar in both fetal liver and brain whereas during postnatal growth this treatment resulted in an increasingly preferential methylation of liver DNA. In 30-day-old and adult rats the concentration of 7-methylguanine in liver was about 8 times higher in brain DNA, suggesting that during prenatal development both liver and brain DNA are transplacentally methylated by a proximate carcinogen produced by maternal organs. Multiple doses of14C-DMPT (50 mg/kg) to adult rats led to a preferential accumulation of O6-methylguanine in cerebral DNA. This supports the hypothesis that the deficient repair excision capacity of the central nervous system is a significant factor in the organ-specific carcinogenicity of DMPT and related carcinogens.This publication has 25 references indexed in Scilit:
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