PERISUPRACHIASMATIC LESIONS ENHANCE THE INCREASE OF GONADOTROPIN-SECRETION IN ACUTELY OVARIECTOMIZED RATS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 79  (2) , 311-314
Abstract
Diestrous female rats were bilaterally lesioned in the perisuprachiasmatic region (peri-SCN region) or in the medial preoptic area (MPOA) and ovariectomized immediately after lesioning. Blood was collected at 1 h before and at 4, 24 and 48 h after surgery. Radioimmunological determination of the serum gonadotropin concentrations revealed that lesioning of the peri-SCN region enhanced significantly the castration-induced increase of FSH and lutropin secretion at 4 and 24 h, whereas MPOA lesions did not influence the serum hormone levels as compared to the sham-lesioned controls. The peri-SCN region, but not the MPOA may be involved in the control of the increase of gonadotropin secretion following ovariectomy in rats.