Placental corticotrophin-releasing hormone: there by accident or design?

Publisher Website
Google Scholar
Abstract
More than a decade has now passed since the first reports that the human placenta contains a peptide displaying corticotrophin-releasing hormone (CRH)-like activity (Shibasaki et al. 1982). This peptide has been shown to be biochemically similar to hypothalamic CRH (Sasaki et al. 1988) and both the CRH gene (Grino et al. 1987) and CRH mRNA (Frim et al. 1988) have been found in placental tissue. Despite some earlier confusion regarding the cellular localisation of CRH (Petraglia et al. 1987, Saijonmaa et al. 1988) the consensus now is that CRH is primarily produced within the syncytiotrophoblast layer of the chorionic villi (Riley et al. 1991, Cooper et al. 1994, Warren & Silverman 1995, Perkins & Linton 1995). The syncytiotrophoblast is bathed in maternal blood providing a direct route for placental CRH to access the maternal circulation in significant amounts. Many studies (Sasaki et al. 1984, Goland et al. 1986, Campbell et

This publication has 0 references indexed in Scilit: