Endogenous Nitric Oxide in Single Exhalations and the Change during Exercise
- 1 November 1993
- journal article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 148 (5) , 1210-1214
- https://doi.org/10.1164/ajrccm/148.5.1210
Abstract
The concentrations of endogenous nitric oxide (NO) and CO2 were measured in exhaled air from healthy humans. During a single exhalation, NO concentrations peaked when the CO2 level reached its plateau. However, whereas CO2 levels remained at a plateau throughout the exhalation, NO concentrations declined after having peaked. After breathholding (5 to 60 s) NO peaked at a higher level than during normal breathing. Nitric oxide concentrations in exhaled air decreased during physical exercise (50 to 100 W). However, taking the increased ventilatory minute volume into account, excretion of NO markedly increased during exercise. The data are compatible with the hypothesis that the NO detected in exhaled air is formed preferentially in the terminal and respiratory bronchioles, and they suggest increased production of NO into exhaled air during exercise and during hyperventilation at rest.Keywords
This publication has 13 references indexed in Scilit:
- Inhaled Nitric Oxide Selectively Reverses Human Hypoxic Pulmonary Vasoconstriction without Causing Systemic VasodilationAnesthesiology, 1993
- Nitric oxide synthase in guinea pig lower airway innervationNeuroscience Letters, 1993
- Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newbornThe Lancet, 1992
- Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.Journal of Histochemistry & Cytochemistry, 1992
- Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits.Proceedings of the National Academy of Sciences, 1992
- Enhancers of nonspecific immunity induce nitric oxide synthase: Induction does not correlate with toxicity or adjuvancyEuropean Journal of Immunology, 1992
- Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humansBiochemical and Biophysical Research Communications, 1991
- Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.Circulation, 1991
- Neuronal NADPH diaphorase is a nitric oxide synthase.Proceedings of the National Academy of Sciences, 1991
- Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivoActa Physiologica Scandinavica, 1990